The Center for Applied Clinical Informatics (CACI) works with informatics researchers to define and use methods for applying data and information to clinical care. We develop and study innovations in clinical informatics to improve clinical outcomes.
Research Highlights
CACI leads in the research and application of clinical informatics principles to clinical care, and the identification and use of methods for improving health and health care with data and information. As a collection of applied researchers, we collaborate to share discoveries and approaches for applying clinical informatics.
We demonstrate and provide support for various informatics approaches, including:
- Integrating cognitive and behavioral informatics techniques
- Clinical decision support
- Supporting clinical reasoning and workflow
- Advanced analytics for clinical data
- Informatics to promote patient safety and quality
- Supporting care continuity across transitions of both providers and patients
- Human factors and human-computer interaction analysis
- Applications of natural language processing
- Creating and using computable phenotypes
- Supporting clinicians adapting to health information technology
- Use of information to support precision care
- Application of biostatistical and machine learning algorithms to clinical data

Adam Wilcox, PhD, FACMI
Director, Center for Applied Clinical Informatics
Professor of Medicine, Division of General Medical Sciences
a.wilcox@wustl.edu

Chih-Hung Chang, PhD
Professor of Occupational Therapy, Medicine and Orthopaedic Surgery
chih-hung.chang@wustl.edu

Sabine M. Dietmann, PhD
Assistant Professor of Developmental Biology and Medicine, School of Medicine
sdietmann@wustl.edu

Mackenzie Hofford, MD
Associate Chief Research Information Officer, School of Medicine
Assistant Professor of Medicine Division of General Medicine School of Medicine
mhofford@wustl.edu

Thomas Kannampallil, PhD, FAMIA
Associate Professor of Anesthesiology
Associate Professor of Computer Science and Engineering, School of Engineering and Applied Science
Associate Chief Research Information Officer, School of Medicine
thomas.k@wustl.edu

Albert M. Lai, PhD, FACMI, FAMIA
Deputy Director, Institute for Informatics, Data Science and Biostatistics (I2DB)
Chief Research Information Officer, School of Medicine
Professor of Medicine, Division of General Medical Sciences
Professor of Computer Science and Engineering, School of Engineering and Applied Science
amlai@wustl.edu

Andrew P. Michelson, MD
Assistant Professor of Medicine, Division of Pulmonary and Critical Care Medicine
amichels@wustl.edu

Po-Yin Yen, PhD, RN, FACMI, FAMIA, FAAN
Associate Professor of Medicine, Division of General Medical Sciences
Associate Professor, Goldfarb School of Nursing, Barnes Jewish College
yenp@wustl.edu
- Alison L. Antes, PhD
Associate Professor of Medicine, Division of General Medical Sciences
For more information on the Center for Applied Clinical Informatics, please email Alicia Cicerelli at acicerelli@wustl.edu.