The Center for Applied Health Informatics (CAHI) works with informatics researchers to define and use methods for applying data and information to clinical care and population health.

We develop and study innovations in informatics to improve both clinical and population health outcomes and work across disciplines to harness the power of data and technology. We strive to improve the lives of patients and communities in St. Louis and beyond.

Research Highlights

The Center for Applied Health Informatics leads in the research and application of informatics principles to clinical care and population health, and the identification and use of methods for improving health and health care with data and information. As a collection of applied researchers, we collaborate to share discoveries and approaches for applying clinical informatics.

The center also provides access to and training in the use of computationally derived (“synthetic”) and health services administrative data. We additionally provide data analysis and visualization services to advance applied clinical and population health research. Learn more about consultations and core services.

We demonstrate and provide support for various informatics approaches, including:

  • Integrating cognitive and behavioral informatics techniques
  • Clinical decision support
  • Supporting clinical reasoning and workflow
  • Advanced analytics for clinical data
  • Informatics to promote patient safety and quality
  • Supporting care continuity across transitions of both providers and patients
  • Human factors and human-computer interaction analysis
  • Applications of natural language processing
  • Creating and using computable phenotypes
  • Supporting clinicians adapting to health information technology
  • Use of information to support precision care
  • Application of biostatistical and machine learning algorithms to clinical data
  • Maintaining data repositories and managing data assets and data dictionaries
  • Training investigators, laboratory staff, and students on the ethical and secure use of data assets
  • Providing leadership on the analysis and visualization of clinical and population health data
  • Facilitating collaboration among interdisciplinary investigators
  • Advancing the use of data to inform researchers and the St. Louis community about health and healthcare
Leadership
Joanna  Abraham, PhD, FACMI, FAMIA

Joanna Abraham, PhD, FACMI, FAMIA

Director, Center for Applied Health Informatics
Professor of Anesthesiology

Publications & Research Interests →

SAFE-T Lab →

Key interests: Handoffs, Perioperative Mental Health, Telemedicine, Clinical Decision Support, Medication ordering, Patient Safety

Click here to read my biography →

CAHI Members
Zachary Abrams, PhD

Zachary Abrams, PhD

Instructor of Biostatistics

Publications & Research Interests →

MyNCBI →

Key interests: AI, Translational Bioinformatics, NLP, Clinical Informatics

Click here to read my biography →

Chih-Hung Chang, PhD

Chih-Hung Chang, PhD

Professor of Occupational Therapy, Medicine and Orthopaedic Surgery

Publications & Research Interests →

Google Scholar →

MyNCBI →

Key interests: Psychometrics, Informatics, Clinical Outcomes, Adaptive Learning Technologies

Click here to read my biography →

Mackenzie Hofford, MD

Mackenzie Hofford, MD

Associate Chief Research Information Officer, School of Medicine
Assistant Professor of Medicine, Division of General Medicine School of Medicine

Publications & Research Interests →

Key interests: Biomedical Informatics, Predictive Modeling, Internal Medicine, Chronic Diseases, Health AI, Clinical Informatics

Click here to read my biography →

Thomas  Kannampallil, PhD, FAMIA

Thomas Kannampallil, PhD, FAMIA

Chief Data Scientist
Assistant Dean for Data Science

Associate Professor of Anesthesiology
Associate Professor of Computer Science and Engineering, School of Engineering and Applied Science

Publications & Research Interests →

Google Scholar →

Key interests: Biomedical Informatics, Pragmatic clinical trials, Human-AI interactions, Applied Clinical Informatics, Patient Safety, Health AI

Click here to read my biography →

Albert M. Lai, PhD, FACMI, FAMIA

Albert M. Lai, PhD, FACMI, FAMIA

Chief Research Information Officer
Assistant Dean for Biomedical Informatics
Deputy Director, Institute for Informatics, Data Science and Biostatistics (I2DB)

Professor of Medicine, Division of General Medicine & Geriatrics
Professor of Computer Science and Engineering, School of Engineering and Applied Science

Publications & Research Interests →

Google Scholar →

MyNCBI →

Key interests: Biomedical Informatics, Telemedicine, Clinical Research Informatics, Consumer Health Informatics, Large Language Models, Natural Language Processing, Health AI

Click here to read my biography →

Sunny  C. Lin, PhD, MS

Sunny C. Lin, PhD, MS

Assistant Professor of Medicine, Division of General Medicine & Geriatrics

Publications & Research Interests →

Google Scholar →

MyNCBI →

Key interests: Health Policy, Health Disparities, Health Care Quality, Health Information Management, Electronic Health Records, Health Care Delivery, Health Information Exchange

Click here to read my biography →

Inez Oh, PhD

Inez Oh, PhD

Assistant Professor of Biostatistics

Publications & Research Interests →

Google Scholar →

MyNCBI →

Key interests: Electronic Health Records, Predictive Modeling, Natural Language Processing, Large Language Models

Click here to read my biography →

Philip R.O. Payne, PhD, FACMI, FAMIA, FAIMBE, FIAHSI

Philip R.O. Payne, PhD, FACMI, FAMIA, FAIMBE, FIAHSI

Director, Institute for Informatics, Data Science and Biostatistics (I2DB)
Janet and Bernard Becker Professor
Vice Chancellor for Biomedical Informatics and Data Science, WashU Medicine
Chief Health AI Officer, BJC Health System and WashU Medicine

Publications & Research Interests →

Google Scholar →

MyNCBI →

Key interests: Health AI, Electronic Health Records (EHRs), Clinical Decision Support, Biomedical Informatics, Clinical and Translational Science, AI

Connect on Bluesky →

Click here to read my biography →

Alexander  S. Plattner, MD, MBA

Alexander S. Plattner, MD, MBA

Assistant Professor of Pediatrics, Infectious Disease

Publications & Research Interests →

Google Scholar →

MyNCBI →

Key interests: Clinical Decision Support, Patient Safety and Quality Improvement, Antimicrobial and Diagnostic Stewardship 

Click here to read my biography →

Beth Prusaczyk, PhD, MSW

Beth Prusaczyk, PhD, MSW

Assistant Professor of Medicine, Division of General Medical Sciences

Publications & Research Interests →

Google Scholar →

MyNCBI →

Key interests: Implementation Science, Health Information Technology, Community-Based Research

Click here to read my biography →

James (Jimmy) Rudloff, MD

James (Jimmy) Rudloff, MD

Assistant Professor of Pediatrics

Publications & Research Interests →

Google Scholar →

Key interests: Pediatric Emergency Medicine, Applied Health Informatics, Clinical Decision Support, Large Language Models

Click here to read my biography →

Ahmed Said, MD, PhD

Ahmed Said, MD, PhD

Associate Professor of Pediatrics, Critical Care Medicine
Medical Co-Director ECMO Program, St. Louis Children’s Hospital

Publications & Research Interests →

MyNCBI →

Ahmed Said Lab →

Key interests: Clinical Decision Support, Predictive Modeling, Translational Biomedical Informatics, Data-driven Critical Care 

Click here to read my biography →

Adam Wilcox, PhD, FACMI

Adam Wilcox, PhD, FACMI

Professor of Medicine, Division of General Medicine & Geriatrics

Publications & Research Interests →

Google Scholar →

MyNCBI →

Key interests: Analytics, Clinical Quality Improvement, Artificial Intelligence, Research Methodology

Click here to read my biography →

Laura K Wiley, PhD, FACMI, FAMIA

Laura K Wiley, PhD, FACMI, FAMIA

Associate Professor of Neurology

Publications & Research Interests →

Google Scholar →

Wiley Lab →

Key interests: Computational phenotyping, Learning Health Systems, Precision Medicine, Clinical Research Informatics

Click here to read my biography →

Po-Yin Yen, PhD, RN, FACMI, FAMIA, FAAN

Po-Yin Yen, PhD, RN, FACMI, FAMIA, FAAN

Deputy Director for Education
Associate Professor of Medicine, Division of General Medicine & Geriatrics
Associate Professor, Goldfarb School of Nursing, Barnes Jewish College

Publications & Research Interests →

Google Scholar →

Key interests: EHR Data Analytics, EHR Documentation, Visual Analytics, AI in Healthcare

Click here to read my biography →

Linying Zhang, PhD

Linying Zhang, PhD

Assistant Professor of Biostatistics

Publications & Research Interests →

Google Scholar →

CausAI Lab →

Key interests: Causal Inference, Federated Learning, Multimodal Foundation Models, Cancer Prevention, Ophthalmology

Click here to read my biography →